We’re excited to share details about the Simple Epidemic-Ending Defense (SEED) system and how it can help prevent epidemics!
The figure illustrates an example of combining a food-safe and unmodified bacterium with an antigen-encoding bacteriophage.
(A) The components are stable for storage and transport. They can be combined in a food-safe matrix prior to administration and/or can be further combined in situ for desired protein antigen production.
(B) The bacteriophage specifically infects the L. lactis cells and repurposes the bacterial machinery for production of phage components and programmed antigen.
(C ) The bacterial cells lyse and release new phage particles, the desired antigen, antigens displayed on the phage, and naturally-occurring adjuvants contributed by the L. lactis cells.
Advantages of the SEED system for global scale access to prevent epidemics and untreatable infections:
We are using our process to produce vaccines against SARS-CoV-2 and the currently spreading highly pathogenic avian influenza (H5N1). The platform can be used to build a large catalog of stable subunit vaccine prototypes. These prototypes can be rapidly added to and modified to address emerging threats and to incorporate beneficial development.
Some key characteristics of the SEED system include: The components are grown rather than synthesized, no antibiotics are required, and no specialized skills or equipment are needed for production or administration.
The point-of-need produced vaccines can be easily administered to vulnerable animals in feed or water to promote a protective mucosal immune response. The low cost, speed, and simplicity of vaccine production and administration provide a needed One Health tool to protect animals (including humans) and lower the risk of spillover to humans.
About GSD Bio:
Greater San Diego Biological Solutions is a San Diego, CA not-for-profit organization, founded and incorporated in November of 2022. Jonathan Moore, PhD (President/Chairperson) and Joe Warner, PhD (Director of Research and Development) are molecular microbiologists who developed industrial enzymes and microbial cell factories at Genomatica, Diversa, and others.
We're committed to preventing epidemics by enabling low-cost immunizations that can be quickly scaled and produced at point-of-need. We’re developing the SEED system for simplified protein production that uses food-safe ingredients and a bacterium used globally in food production.
The SEED system (Lactococcal phage-vectored protein production at point-of-need) is patent-pending.
Copyright © 2024 GSD Bio - All Rights Reserved. Greater San Diego Biological Solutions is a 501(c)(3) nonprofit public benefit corporation. TAX ID: 88-4283342
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